eLD: entropy-based linkage disequilibrium index between multiallelic sites
نویسندگان
چکیده
منابع مشابه
GENETICS | INVESTIGATION Sporadic, global linkage disequilibrium between unlinked segregating sites
Demographic, genetic, or stochastic factors can lead to perfect linkage disequilibrium (LD) between alleles at two loci without respect to the extent of their physical distance, a phenomenon that Lawrence et al. (2005a) refer to as “genetic indistinguishability”. This phenomenon can complicate genotype-phenotype association testing by hindering the ability to localize causal alleles, but has no...
متن کاملSporadic, Global Linkage Disequilibrium Between Unlinked Segregating Sites.
Demographic, genetic, or stochastic factors can lead to perfect linkage disequilibrium (LD) between alleles at two loci without respect to the extent of their physical distance, a phenomenon that Lawrence et al. (2005a) refer to as "genetic indistinguishability." This phenomenon can complicate genotype-phenotype association testing by hindering the ability to localize causal alleles, but has no...
متن کاملLinkage disequilibrium between loci with unknown phase.
Linkage disequilibrium is often measured by two statistics, D and r, which can be interpreted as the covariance and the correlation between loci and across gametes. When data consist of diploid genotypes, however, gametes cannot be identified. A variety of iterative statistical methods are used in such cases, all of which assume random mating. Previous work has shown that D and r can be express...
متن کاملLinkage disequilibrium extends across putative selected sites in FOXP2.
Polymorphism data in humans suggest that the gene encoding the transcription factor FOXP2, which influences speech and language development, has been subject to a selective sweep within the last 260,000 years. It has been proposed that one or both of two substitutions that occurred on the human evolutionary lineage and changed amino acids were the targets for selection. In apparent contradictio...
متن کاملLDA - a java-based linkage disequilibrium analyzer
UNLABELLED We describe an integrated java-based program that provides elaborate graphic and plain-text output of pairwise linkage disequilibrium (LD) analysis of single nucleotide polymorphisms genotypic data. It is most suitable for molecular geneticists, who are focusing on LD measures estimation, statistical significance test and extent prediction. AVAILABILITY The software is available at...
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ژورنال
عنوان ژورنال: Human Genome Variation
سال: 2018
ISSN: 2054-345X
DOI: 10.1038/s41439-018-0030-x